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    • In pharmaceutical formulation development, following the "Quality by Design" (QBD) principle, it is essential to explore the operational space that meets the product's critical quality attributes (CQA). For hot melt extrusion, this operational space depends on the system's torquethe greater the torque, the greater the process window. To meet this need, PPS developed the second-generation PPS TSE16 P hot melt extrusion system, offering a torque of up to 30Nm. This system can handle high-viscosity excipients, avoiding shutdown risks due to torque limits, and provides researchers with sufficient process window to find the best production processes ensuring product CQA.